Following the excellent performance and win over Harrow Borough, the Rebels starting eleven was unchanged and they were able to welcome Steve Daly back onto the bench following an injury which forced him to miss the game in midweek.
Slough elected to play on the counter for the first half and the tactic worked well for the Rebels for the majority. Paul Abbott should have given the home side the lead as he was provided with a glorious opportunity from James Pinnock's centre, the forward could only divert the ball over the bar from a few yards out.
Lee Protheroe went close from a free kick and then Slough had their best chance of the half through Adam Wallace. Matt Glynn worked his way into the box and put the ball across to Jamie Jarvis, his touch was seized upon by Wallace which beat Chalmers-Stevens but was blocked on the line before being hacked away.
The striker was not to be denied and opening his Rebels account three minutes before half time. Reciving the ball from Glynn, Wallace took a touch inside and then placed his effort low into the far corner to put the Rebels in a surprise, but not entirely undeserved, one nil lead which they carried through into half time.
It took the home side just nine second half minutes to restore parity on the scoreline as the prolific Danny Hockton headed home a cross from the right at the near post to equalise for Margate.
Within two minutes, the home side were in front. Protheroe's ball in from the right bounced just too high for Steve Dell and Jimmy Jackson was able to receive the ball behind the defender and lash home past Drake.
Hockton forced Drake into a good save with the striker running off the back of Marc Leach to get onto Greg Oates' through ball. Turning in past Jamie Jarvis and with a clear sight of goal, but the Slough keeper was out quickly and got a good hand to the strikers effort.
Slough moved Marc Leach upfront in the closing stages in the hope of finding a way back into the game, but the home side remained the more dangerous of the two and held on comfortably for their win.
Margate Line up
Scott Chalmers-Stevens, Greg Oates, Justin Skinner, Lee Protheroe, Robin Trott, James Donovan, Daniel Wisker(12), Paul Abbott(14), James Pinnock, Danny Hockton, Jimmy Jackson. Subs: Dean Standen(7), Aaron Robinson(8), Charlie Mitten, Chris Wild, Louis Smith.