Slough handed debuts to summer signings Kieron Drake, Marc Leach, Matt Glynn, Adam Wallace and Anaclet Odhiambo whilst Daryl Harris and Alex Gibson had places on the bench alongside the returning Mark Bartley.
Slough were missing Jamie Jarvis and Steve Dell, also having joined over the summer, through suspension so Garath McCleary had to take up an unfamiliar wing back role in the absence of Dell.
The away side had the games opening chance as the ball was fed in from the right. Edmond Protain ran in and tried to flick the ball past the onrushing Drake but failed to make contact and McCleary was able to clear for Slough.
Protain again had another opportunity to open the scoring for Leyton. Ian Lovegrove failed to clear the ball for Slough and it was worked over to the winger who in space from the middle of the D, placed his effort wide.
Drake made a good save from Steve West following a Leyton counter, with his legs blocking a low drive as the striker got a shot away from inside the area.
Any sight Slough did get of the Leyton goal in the first half resulted in wild attempts which didn't find the target and James Hassell enjoyed an easy first half.
The breakthrough came in the sixth minute of the second half. A cross in from the left hand side was headed away by Slough but the ball fell to Rio Alderton and the midfielder put in a sweet drive which flew into Drake's left hand corner.
Leyton continued to have the better of the match and Lela Bajada should have done better when well placed and clear on the left hand side of the area but could only blaze well over.
Protain had another good strike pushed away by Drake, who did well to gather the rebound from the feet of David Morgan.
Slough pushed McCleary further forward as they looked to get back into the game and the wide player was their best attacking outlet in a more familiar position higher up the pitch.
Slough's only chance of note for the whole game came from a direct free kick from Glynn in injury time which Hassell comfortably turned around the post.
Leyton Line up
James Hassell, Des Thomas, Vas Soteriou, Dean Palmer, Scott Honeyball, Rio Alderton, Loui Fazackerley, Lela Bajada, Steve West, Mark Sophocleous, Edmond Protain. Subs: Frank Curley, David Morgan, Danny Tenkorang, James Bunn, Manny Williams.