The Rebels gave a league debut to Tyrese Owen who signed from Kingstonian on Monday, in what was two changes from the Rebels’ defeat to Welling United.
In only the fourth minute, the hosts got off to the perfect start.
After a contentious foul was awarded for a shove near the corner flag, Kieran Murtagh rose highest to nod home a free kick having found space in the penalty box.
The Rebels responded well as Elliot Benyon headed just wide after ghosting in at the back post, meeting a sumptuous cross from the left by Matt Lench.
Midway through the first half Will Dennis had to be alert to deny Malachi Napa twice in quick succession, getting down low to palm away the danger.
Set pieces were proving to be a problem for Slough, with the defence clearing a header off the line after a Dartford corner from the right.
The Rebels improved as the half went on as they managed to get hold of the ball in midfield.
On 34, Lench fired over from the edge of the box after good work from Benyon holding up the ball amongst a couple of Dartford defenders.
The Rebels applied pressure before the interval and almost found a route to goal in first half stoppage time.
Josh Jackman did well down the right, beating his man before delivering a low cross which Benyon fired just wide from a tight angle.
The hosts had a lively start to the second half, the lively Napa cut inside from the right and drove the ball towards goal, but his effort was deflected wide of the target.
Luke Coulson then tested Dennis from distance as the Slough stopper tipped the ball away to safety.
Shortly after, Connor Essam rose highest in the box and headed straight into the arms of Dennis.
On 57, the Darts had a golden chance to double the advantage after some slack play from Slough.
Murtagh profited from a lapse in concentration but dragged his shot wide of the target when he ought to have at least tested Dennis.
A vociferous Rebel contingent attempted to rally the side to a leveller. Lench got in behind the Dartford defence, but his cut back was intercepted by Ben Dudzinski between the sticks.
Dartford were managing the game well and on 80 conjured an opening which saw Alex Wall slice an effort just wide from a tight angle on the left side of the box.
Slough were lacking forward thrust, but substitute Moe Shubbar ran directly at the Dartford backline before seeing his powerful strike drift wide.
In the closing stages, Dartford closed the game out comfortably to take the three points in what was a disappointing evening on the road.
The Rebels are on the road once again this Saturday as they head to St Albans City looking to end a run of three straight defeats.
Dudzinski, Wynter, Essam, Bonner, Coulson, Wall, Murtagh, Ogundea, Smith, Meade, Napa. Substitutes: Wilks, Carruthers, Onyeagwara, Statham, Fonkeu.