The Rebels have now won five consecutive league games and have also now beaten last season’s points tally of 85, as well as moving into treble figures for league goals scored.
The returning Chris Flood hit a hat-trick on the night as Slough again run the changes – six in total from the win at Stratford on Saturday, including a first league start for Harrison Gilkes.
Biggleswade’s goalkeeper crisis has been well documented, but stand-in keeper Craig Daniel made a good save early on to push a shot over the bar.
However, it took just seven minutes for Flood to make his mark. The striker converted a loose ball after Gilkes had beaten Daniel to the ball following a low cross into the box from George Wells.
The lead was doubled on 18 minutes with Flood taking a pass from Manny Williams and firing in a low shot across Daniel which he could not get a touch to.
Slough were comfortable and extended their lead further as Williams volleyed in on 37 minutes after Scott Davies had crossed into the box.
The Rebels had been much the better side, but Jon Underwood and Neil Baker admitted they had warned against complacency at half time as they expected a response from Biggleswade – and in the end, the home side went close to recovering the deficit.
The play moved from end to end early in the second half – the home side hit the post, and moments later Slough could have scored their fourth, but Gavin Hoyte did well to clear off the line from Williams.
Shortly after, Nathan Hicks produced a fine finish after a run and cross from Greg Kaziboni as Biggleswade pulled one back.
Just four minutes later, the comeback was on as Connor Hall turned the ball home at the near post after a free kick was played in.
Slough’s response to this was quick however, and on 64 minutes Flood completed his treble, heading Sean Fraser’s cross past Daniel having got free of his marker – scoring the Rebels’ 100th league goal of the season in the process.
Ten minutes later, the Waders scored again – this time Kaziboni the man to beat Jack Turner after turning well and firing into the bottom corner – and Biggleswade continued to pile on the pressure, with the same player getting into a good position in the box but unable to get a shot away.
George Bailey fired in a shot from the edge of the box which Turner saved well, before Jack Bowen went closer still, seeing his header come back off the crossbar.
Substitute Perry Coles added a fifth for Slough in the final moments of the match with a smart finish across Daniel into the opposite corner as the Rebels finally made sure of another three points.
Biggleswade Town Line up
Craig Daniel (c), Jordan Patrick, Lucas Perry, Reece Fielding, Nathan Hicks, Gavin Hoyte, Greg Kaziboni, Connor Hall, Jack Bowen, Robbie Parker, Tony Burnett (George Bailey). Unused substitutes: Luca Allinson-Stalham, Sam Elliot, Taishan Griffiths, Mark Coulson.